2015 Annual Science Report

Massachusetts Institute of Technology Reporting  |  JAN 2015 – DEC 2015

Ancient Gene Families and HGT

Project Summary

We have identified a subset of genes that appear to have been horizontally transferred from very ancient lineages that diverged earlier than the ancestor of the 3 known Domains of life.

4 Institutions
3 Teams
2 Publications
0 Field Sites
Field Sites

Project Progress

We have shown that anomalous forms of highly conserved protein families are found within a derived subset of genomes, in this case, seryl- and threonyl- amionacyl-tRNA synthetases, have a phylogenetic history consistent with these genes being horizontally transferred from very ancient lineages that diverged earlier than the ancestor of the 3 known Domains of life. Observing these kinds of ancient “hypnolog” genes is predicted by coalescent theory, and supports models that the earliest cellular life had a diversity rooted deeper than the Last Universal Common Ancestor (LUCA). This result also implies that these other deep lineages survived for some time alongside the extant Domains, likely at least into the Archean, so that genes could continue to be transferred to more derived lineages within Archaea and Bacteria. Furthermore, this work illustrates that LUCA is not necessarily the singular ancestral source of all ancient gene families.

  • PROJECT INVESTIGATORS:
    Greg Fournier Greg Fournier
    Project Investigator
  • PROJECT MEMBERS:
    Eric Alm
    Co-Investigator

  • RELATED OBJECTIVES:
    Objective 3.2
    Origins and evolution of functional biomolecules

    Objective 3.4
    Origins of cellularity and protobiological systems